Journal Club
During the academic year, our PhD students present a journal article on most Wednesdays at 7:30 a.m., in the Lecture Hall (E501).
JOURNAL CLUB
"A single-cell atlas of the mymetrium in human parturition"
Recent Journal Club
JOURNAL CLUB
"Mechanistic insight into bacterial entrapment by septin cage reconstitution"
JOURNAL CLUB
"Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING"
JOURNAL CLUB
"Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain"
JOURNAL CLUB
"Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia"
JOURNAL CLUB
"Members of the KCTD family are major regulators of cAMP signaling"
JOURNAL CLUB
"Acid-sensing receptor GPR4 plays a crucial role in lymphatic cancer metastasis"
JOURNAL CLUB
"Metformin decelerates aging clock in male monkeys by Yuanhan Yang, Xiaoyong Lu, Ning Liu, Jing Qu, Weiqi Zhang, Guang-Hui Liu"
Archived Journal Club
JOURNAL CLUB
"Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum"
JOURNAL CLUB
"A phosphoinositide signalling pathway mediates rapid lysosomal repair"
JOURNAL CLUB
"Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration"
JOURNAL CLUB
"SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis"
JOURNAL CLUB
"GLP1R Attenuates Sympathetic Response to High Glucose via Carotid Body Inhibition" by Pauza et al, published in Circulation Research in 2022"
JOURNAL CLUB
"Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure"
JOURNAL CLUB
"Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice"
JOURNAL CLUB
"Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle"
JOURNAL CLUB
"Bassoon contributes to tau-seed propagation and neurotoxicity"
JOURNAL CLUB
"Bassoon contributes to tau-seed propagation and neurotoxicity"
JOURNAL CLUB
"Prolonged sleep deprivation induces a cytokinestorm-like syndrome in mammals"
JOURNAL CLUB
"Structural titration reveals Ca2+-dependent conformational landscape of the IP3 receptor"
JOURNAL CLUB
"NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells"
JOURNAL CLUB
"Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling"
JOURNAL CLUB
"The long noncoding RNA ADIPINT regulates human adipocyte via pyruvate carboxylase"
JOURNAL CLUB
"Structures of the TMC-1 complex illuminate mechanosensory transduction"
JOURNAL CLUB
"Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons"
JOURNAL CLUB
"Cardiac pericytes mediate the remodeling response to myocardial infarction (rescheduled from Sept. 13)"
JOURNAL CLUB
"Single-cell intracellular pH dynamics regulate the cell cycle by timing the G1 exit and G2 transition"
JOURNAL CLUB
"High dietary salt amplifies osmoresponsiveness in vasopressin-releasing neurons"
JOURNAL CLUB
"Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery"
JOURNAL CLUB
"IL-23 secreted by myeloid cells drives castration-resistant prostate cancer "
JOURNAL CLUB
"Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs"
JOURNAL CLUB
"Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics"
JOURNAL CLUB
"Transient cell-in-cell formation uderlies tumor relapse and resistance to immunotherapy"
JOURNAL CLUB
"Hepatic thyroid hormone signaling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism"
JOURNAL CLUB
"Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration"
JOURNAL CLUB
"Kinetic Tracking of Plasmodium falciparum Antigens on Infected Erythrocytes with a Novel Reporter of Protein Insertion and Surface Exposure "
JOURNAL CLUB
"Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy"
JOURNAL CLUB
"Progerin modulates the IGF-1R/Akt signaling involved in aging"
JOURNAL CLUB
"Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer"
JOURNAL CLUB
"Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer"
JOURNAL CLUB
"Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis"
JOURNAL CLUB
"Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins"
JOURNAL CLUB
"Biological chemotaxis-guided self-thermophoretic nanoplatform augments colorectal cancer therapy through autonomous mucus penetration"
JOURNAL CLUB
"Neutrophil extracellular traps-triggered impaired autophagic flux via METTL3 underlies sepsis-associated acute lung injury"
JOURNAL CLUB
"Embryo model completes gastrulation to neurulation and organogenesis"
JOURNAL CLUB
"Collagen-binding peptides for the enhancedimaging, lubrication and regeneration of osteoarthritic articular cartilage"
JOURNAL CLUB
"Maturation and circuit integration of transplanted human cortical organoids"
JOURNAL CLUB
"USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor α"
JOURNAL CLUB
"Inceptor counteracts insulin signalling in β-cells to control glycaemia"
JOURNAL CLUB
"Low-dose metformin targets the lysosomal AMPK pathway through PEN2"
JOURNAL CLUB
"Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity"
JOURNAL CLUB
"TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A"
JOURNAL CLUB
"Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue"
JOURNAL CLUB
"CRISPR/Cas9-mediated knockout of SGLT1 inhibits proliferation and alters metabolism of gastric cancer cells"
JOURNAL CLUB
"Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis"
JOURNAL CLUB
"Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth"
JOURNAL CLUB
"Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death"
JOURNAL CLUB
"Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span"
JOURNAL CLUB
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Reduced GABAergic Neuron Excitability, Altered Synaptic Connectivity, and Seizures in a KCNT1 Gain-of-Function Mouse Model of Childhood Epilepsy
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JOURNAL CLUB
"Reprogramming to recover youthful epigenetic information and restore vision"
JOURNAL CLUB
"Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells"
JOURNAL CLUB
"Low glycaemic diets alter lipid metabolism to influence tumour growth"
JOURNAL CLUB
"Mitochondrial translation is required for sustained killing by cytotoxic T cells"
JOURNAL CLUB
"POSTPONED TO A DATE TBD: Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis"
JOURNAL CLUB
"ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H+-ATPases is essential for brain development in humans and mice "
JOURNAL CLUB
"Parabrachial CGRP Neurons Control Meal Termination
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JOURNAL CLUB
"O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’sdisease by inhibiting necroptosis
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JOURNAL CLUB
"Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition
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JOURNAL CLUB
"Computational design of transmembrane poressis
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JOURNAL CLUB
"Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
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JOURNAL CLUB
"mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
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JOURNAL CLUB
"Platelets docking to VWF prevent leaks during leukocyteextravasation by stimulating Tie-2
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JOURNAL CLUB
"Tolerance to Morphine-Induced Inhibition of TTX-R Sodium Channels in Dorsal Root Ganglia Neurons Is Modulated by Gut-Derived Mediators
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JOURNAL CLUB
"Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer
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JOURNAL CLUB
"A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis
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JOURNAL CLUB
"Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice
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JOURNAL CLUB
"Age-induced accumulation of methylmalonic acid promotes tumour progression
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JOURNAL CLUB
"Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms
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JOURNAL CLUB
"Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
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JOURNAL CLUB
"GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
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JOURNAL CLUB
"Importin a3 regulates chronic pain pathways in peripheral sensory neurons
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JOURNAL CLUB
"RESCHEDULED FROM JANUARY 8: DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome
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JOURNAL CLUB
"Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension
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JOURNAL CLUB
"Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological alpha-Synuclein Insult
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JOURNAL CLUB
"Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway
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JOURNAL CLUB
"Cystic fibrosis–adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses
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JOURNAL CLUB
"A new antibiotic selectively kills Gram-negative pathogens
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JOURNAL CLUB
"Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease
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JOURNAL CLUB
"Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization
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JOURNAL CLUB
"Metabolic regulation of gene expression by histone lactylation
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JOURNAL CLUB
"Habenular TCF7L2 links nicotine addiction to diabetes
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JOURNAL CLUB
"Regulation of lifespan by neural excitation and REST
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JOURNAL CLUB
"Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
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JOURNAL CLUB
"FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells
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